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Animal Research System(동물연구)

[Toxicology System] Animal Inhalation System, Complete Toxicology Systems, Toxicology, Animal InExpose System

[Toxicology System] Animal Inhalation System, Complete Toxicology Systems, Toxicology, Animal InExpose System

 

 

Harmful effects of tobacco smoke exposure Research System !

Cigarette Smoking SystemAnimal tobacco smoke exposure research system

 

Animal InExpose research System !

Complete Toxicology System !

 

Animal Inexpose research systemTobacco studies, E-Cigarettes and Vaping reserch system

 

Tobacco Studies, E-Cigarettes & Vaping Research

- Scientific evidence is also needed to understand the risks associated with vapour exposure from electronic cigarettes (e-cigarettes)

- Guide the decision-making process for the use of these nicotine delivery devices.

- The rapid adoption of e-cigarettes, especially amongst the youth, has spurred a rush to fill the knowledge gap pertaining to the safety profile for the users and the environment.

 

Amimal smoking effect research systemResearch of Risk associated with vapour exposure

 

Basic System

The inExpose is a modular, compact inhalation exposure system with precise computer controlled functionality managed by our flexiWare software.

 

Compact inhalation exposure systemStudies of effects of tobacco exposure

 

 

The basic inExpose system includes the following

- Base unit: houses electronics for pumps, data acquisition and accessory control.

- Pump(s): servo-controlled to deliver constant or time-varying flow profiles.

- Exposure platform: both nose-only and whole body exposure options.

- Software: manages inExpose components, data acquisition, display and data archiving in real-time.

 

 

Exposure Platforms

COMPACT AND EFFICIENT

Animal Exposure Testing SsytemNose only and towers and whole body chambers

 

- Offers nose-only towers and whole body chambers which tightly integrate with inhalant generation devices, minimizing flow pathways and maximizing delivery efficiency.

- Compact exposure platforms are utilized for small rodent inhalation exposure, and some can also be adapted for short in-vitro exposure protocols.

 

Animal Toxicology systemCompact exposure platform system

 

 

NOSE-ONLY TOWER

- The nose-only towers are constructed with individual air-flow pathways to ensure uniform inhalant distribution, and prevent re-breathing of air among subjects.

- The small internal volume design enables a tower to reach target concentrations with minimum compound usage when compared to conventional larger towers.

- Each tower can support 12 mice or 4 rats and multiple towers can be run in parallel with a single base unit.

- Complementing the nose-only tower are our unique, comparatively gentle Soft RestraintsTM for mice (or neonate rats), which are constructed from flexible, coated wires that conform to a mouse’s body shape, thereby avoiding thoracic restriction and body overheating.

- When exposing other species, standard rigid restraints are available in a variety of sizes. 

 

WHOLE BODY CHAMBER

- The whole body chambers contain small internal volumes and 8 symmetric exposure ports, allowing for even distribution throughout the chamber.

- Due to the unrestrained nature of this exposure, experiments may continue for longer periods and are generally regarded to be less stressful for subjects.

- Each chamber can house approximately 12-24 freely moving mice or 3-6 rats.

- Separators are available for both mice and rats to isolate subjects and eliminate the possibility of subjects huddling together, which may impede effective inhalation.

 

Animal Smoking Exposure SystemWhole body chamber system

 

 

IN-VITRO EXPOSURE

- Turn-key inExpose smoke setups are available to produce cigarette smoke extract solutions or perform in-vitro cell culture exposure for smoke and aerosol applications.

- In-vitro exposure protocols typically call for constant flows with steady-state concentrations.

- Given the small internal volumes of the exposure hardware and complete control of the flexiWare software, the inExpose is ideally positioned to deliver particulates to cells.

 

 Inexpose smoke setup systemAnimal Smoking Testing System

 

 

Aerosol Generation

INTEGRATING THE AERONEB

- The inExpose integrates with Aeroneb ultrasonic nebulizers to provide a turn-key aerosol generation solution.

- The nebulizer is directly attached onto the intake ports of the exposure platforms to efficiently utilize precious compounds by minimizing losses in conduits and reaching desired concentrations quickly.

 

Animal smoking testinf systemSmart integrate Toxicology design system

 

 

CONTROLLED AEROSOL GENERATION AND DELIVERY

- Beyond aerosol generation from aqueous solutions, the Aeroneb nebulizer successfully nebulizes ovalbumin mixtures, nanoparticle suspensions, polysaccharide suspensions, protein solutions, and DNA fragments without denaturation.

- Through the powerful flexiWare software, the inExpose permits precise control of nebulization rates, whereas the servo-controlled pumps regulate flows in the exposure platforms.

- Offers two standard models of Aeroneb nebulizers that are suitable for most research needs.

- For specific applications such as fungi suspension nebulization, SCIREQ offers a customized Aeroneb nebulizer of ~11 VMD.

 

 

Smoke and Vape Generation

CUSTOMIZE YOUR PUFF PROFILES

- The inExpose can be configured to genrate cigarette smoke, e-cigarette smoke, vaping, hookah smoke, etc. to fit a wide range of applications and budgets.

- Our devices are designed to produce both ISO standard and customized puff profiles, defined by the researcher.

- Moreover, the inExpose can be configured to deliver side-stream smoke, main-stream smoke or a mixture of both.

 

Smoking Testing SystemSmart research design system

 

 

CIGARETTE SMOKING ROBOT

- The computer-controlled cigarette smoking robot allows 1 to 12 cigarettes to be smoked in any possible parallel or sequential combination, permitting the instrument to run for up to four hours without user intervention.

- It also features automatic cigarette lighting, smoking and ejection in user-programmable sequences. 

 

SINGLE CIGARETTE CHAMBER

- The single cigarette chamber features a single cigarette holder to allow for manual loading, lighting and removal of cigarettes.

- This setup is ideal for experiments with short exposure protocols and low smoke concentrations.

- The sigle cigarette chamber also allows for vape exposure through a customized adapter that accommodates puff-activated e-cigarettes with a mouth piece diameter from 6.5mm to 10.5 mm.

 

E-CIGARETTE VAPE GENERATION

- The e-cigarette extension is designed for the push button 3rd generation “MOD” e-cigarettes.

- This extension allows for longer exposures due to a larger tank, offers automated activation, custom puff profiles, and temperature control of the vapour produced.

 

 Animal inhalation systemAnimal exposure reserach system

 

Atmospheric Monitoring

QUANTITATIVE AND QUALITATIVE

- Comprehensive monitoring and recording of the exposure atmosphere, such as qualitative particulate measurements by infra-red opacity, quasi-quantitative particulate concentrations and gravimetric measurements are available and easily integrated as part of the inExpose solution.

- While gravimetric measurements are collected at the end of the experimentation session, particulate concentrations are displayed in the flexiWare software in real-time and may be recorded continuously or at the researcher’s discretion.

 

 

Evacuation

EXHAUST CONTROL

- Exhaust management and operator safety is important with all inExpose configurations.

- We recommend performing all experiments within a fume hood with exhaust directed to the vents.

- More advanced evacuation solutions, such as particulate filters, active charcoal filters, aqueous or buffered scrubber solutions can be easily integrated to the exhaust ports of the inExpose.

 

Smoking Exposure systemAnimal Smoking Research System

 

 

- Specifically for smoking applications, adequate exhaust is necessary to maintain cigarette lighting efficiency and consistent puffing.

- Offers an adjustable exhaust flow system to ensure that no smoke accumulates in the cigarette smoking robot (CSR) and that the cigarettes are properly aspirated.

 

 

System Accessories

- System will provide suitable accessories based on the purchase of your inExpose system configuration.

- Some items are considered disposable and will need to be replaced over time or after heavy use.

- Common replacement items include: tubing kits, pump valves and fittings, as well as filters.

- Rotameters, computers, cables, power supplies and other small tools may also be acquired as needed.

 

 

Contact & Ask

Medical Device Korea

TEL : 02 553 0923

 

www.medicaldevice.kr